GastroPlus 10.2: Physiologically Based PBPK/PBBM Modeling Software
GastroPlus 10.2 (GPX.2) is Simulations Plus’ latest major release of the physiologically based pharmacokinetic (PBPK) modeling software. Described as “the largest upgrade ever,” this version introduces the ACATPlus GI model, AI-powered tools, and significant automation enhancements .
Key New Features in Version 10.2
ACATPlus Advanced GI Model
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Expanded Compartments: Extended from classic ACAT model to 13 compartments with new colon sub-divisions (ascending, transverse, descending, sigmoid, rectum) and detailed tissue layers (mucus, mucosa, submucosa, muscle)
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Microbiome Metabolism: Simulates compound transformation by gut microbiota
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Local Tissue Concentrations: Predicts drug levels in intestinal tissues, critical for locally acting drugs
New Dosing Routes
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Intramuscular (IM) & Subcutaneous (SubQ) Models: Simulate long-acting injectable formulations; accounts for particle size, injection site blood flow, and tissue properties
AI-Powered Tools
| Tool | Function |
|---|---|
| AssessmentsPlus | Provides modeling recommendations and generates summary reports with optimization suggestions based on built-in expert knowledge |
| Data Extractor | AI-driven tool to digitize and extract structured data from charts and table images |
| GastroPlusGPT | 24/7 technical support assistant answering software and module questions |
Automation & Workflow
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Orchestrator: REST API enabling R/Python scripting for automated, reproducible, standardized workflows; supports global sensitivity analysis, batch simulations, and external tool integration
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P-PSD Module: Fits particle size distribution from dissolution data