Lhasa Nexus 2.7: The In Silico Platform for Chemical Safety Assessment
Lhasa Nexus 2.7 is a specialized software suite for predictive toxicology and metabolism, primarily used in pharmaceutical development, chemical safety, and regulatory science. It applies expert knowledge and computational models to predict the potential toxicity and metabolic fate of chemical compounds, helping researchers prioritize experiments, mitigate risks, and support regulatory submissions.
Core Function: Virtual Screening for Chemical Hazards
The software’s primary function is to provide early, computer-based (“in silico”) assessments of a molecule’s safety profile. It helps answer critical questions: “Could this compound be mutagenic, carcinogenic, or toxic?” and “How will the body metabolize it?” before costly laboratory or clinical testing begins.
Key Functions:
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Toxicity Prediction: Utilizes well-established methodologies (e.g., Derek Nexus) to predict a wide range of toxicological endpoints, including mutagenicity, carcinogenicity, skin sensitization, and organ toxicity, based on structural alerts and reasoning.
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Metabolism Prediction: Employs tools (e.g., Meteor Nexus) to predict the likely metabolic pathways and metabolites of a compound in humans and other species, which is crucial for understanding drug efficacy, toxicity, and drug-drug interactions.
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Knowledge-Based Management: Centralizes and manages chemical data, experimental results, and predictions in a structured database, facilitating knowledge sharing and regulatory reporting within organizations.
